A failed Pfizer clinical trial for a meningitis treatment conducted in Nigeria was referenced in several recent social media posts about the origins of modern vaccine hesitancy in Africa. The 1996 trial was held in Kano, Nigeria, at the height of Africa’s worst meningitis outbreak and left 11 children dead and dozens more with debilitating injuries. In response to a post about why the COVID-19 vaccination rates in Africa remain low, one social media user claims that Africans “learned to never trust the vax,” and another user references a documentary about the Kano trial, incorrectly calling it a polio vaccine trial. A Nigerian physician explained the ethical issues involved with the trial and the lasting impact it had on vaccine acceptance in the country. Notably, because a majority of the family harmed in the trial was Muslim, some religious leaders at the time accused Western companies and institutions of targeting Muslims with vaccines, a belief that persists and continues to fuel vaccine hesitancy. Conversations about the documentary are circulating worldwide.